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Failure of Un-Reinforced Masonry (URM) infilled Reinforced Concrete (RC) frame buildings during Bhuj earthquake highlighted the need for vulnerability assessment of existing stock of such buildings in India. Indian Standard, like many other national codes, does not provide any guideline for modeling of infills and explicit insight into the vulnerability of the infilled frames. For reliable estimation of fragility parameters for existing URM infilled RC frame buildings in India, a parametric study has been carried out for representative building selected from field survey in India (DEQ 2009), considering different parameters affecting the seismic performance of buildings. Infill panels are represented by macro model (Haldar and Singh 2012) with stiffness as defined in ASCE-41 (2007) and strength obtained from the weakest failure mode. Sequential analysis is performed to take into account the construction sequence of infill panels relative to frames. HAZUS (FEMA 2003, 2006) methodology along with nonlinear static analysis is used to estimate seismic vulnerability functions.